A “Malaria Box” that could hold the answer to discovering new drugs to treat tropical diseases and cancer has been created for researchers around the world. Griffith University tropical disease researchers have joined together with a host of international laboratories to advance drug discovery for major topical diseases through the creation and testing of the Malaria Box. In a paper published this week in the top journal PLoS Pathogens, the global team present findings on a panel of 400 chemical compounds – dubbed the “Malaria Box” – with potential application as therapeutic starting points for diseases like malaria, trypanosomiasis and toxoplasmosis.
toxoplasmosis
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A Law Professor’s Big Idea for Combating Greedy Drug Company Titans Like Martin Shkreli
Noah Berlatsky | Quartz | September 21, 2017
In 2015, CEO of Turing Pharmaceuticals Martin Shkreli infamously raised the price of the life-saving drug Daraprim by 5,000%. Daraprim, developed more than 60 years ago, is used to treat the deadly parasitic infection toxoplasmosis. It was selling for $13.50 a pill; then Turing raised the price to $750. The move sparked massive backlash and Congressional hearings, and Shkreli himself was eventually arrested for, and convicted of, unrelated securities fraud charges. But the original, horrible problem didn’t get fixed. Turing kept the price sky-high; as of August 2016, many patients were paying $375 per pill...
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Australian High School Students Use Open Source to Make Shkreli's $750 Drug For Less Than $2
Press Release |
University of Sydney |
November 30, 2016
Sydney Grammar students, under the supervision of the University of Sydney and global members of the Open Source Malaria consortium, have reproduced an essential medicine in their high school laboratories. The drug, Daraprim, had been the subject of controversy when the price was hiked from US$13.50 to US$750 a dose last year. Daraprim - originally used as an antimalarial after its synthesis by Nobel Prize winner Gertrude Elion - is now more widely used as an anti-parasitic treatment for toxoplasmosis, which can be a dangerous disease for pregnant women and people with compromised immune systems, such as those living with HIV or AIDS...
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Breaking Good: School Students Make Costly Drug Cheaply Using Open Source Approach
Press Release |
University of Sydney |
November 30, 2016
Sydney Grammar students, under the supervision of the University of Sydney and global members of the Open Source Malaria consortium, have reproduced an essential medicine in their high school laboratories. The drug, Daraprim, had been the subject of controversy when the price was hiked from US $13.50 to US$750 a dose last year. Daraprim - originally used as an antimalarial after its synthesis by Nobel Prize winner Gertrude Elion - is now more widely used as an anti-parasitic treatment for toxoplasmosis, which can be a dangerous disease for pregnant women and people with compromised immune systems, such as those living with HIV or AIDS...
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Epipen: A Sign of a Broken Healthcare System
Tanya Feke | Diagnosis Life, LLC | October 13, 2016
It has been going on for years. The difference is that now the media is hopping on the story. Now America is paying attention. In 2015, the price of doxycycline, a generic antibiotic, was up to $5 per pill, an increase from $0.03 in 2014. The antibiotic is the gold standard treatment for Lyme disease. In 2015, the price of Daraprim (pyrimethamine), was up to $750 per pill, an increase from $13.50. The antiparasitic medication is used to toxoplasmosis, an infection acquired in people who have HIV/AIDS...
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Griffith Scientists Unlock the “Malaria Box”
Press Release |
Griffith University |
August 1, 2016
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Open Source Malaria Helps Students with Proof of Concept Toxoplasmosis Pill
Paul Mutter | Geek Time | December 3, 2016
A team of Australian student researchers at Sydney Grammar School has managed to recreate the formula for Daraprim, the drug made (in)famous by the actions of Turing Pharmaceuticals last year when it increased the price substantially per pill. According to Futurism, the undertaking was helped along by an, “online research-sharing platform called Open Source Malaria [OSM], which aims to use publicly available drugs and medical techniques to treat malaria”...
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